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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
2.12
Human Site:
S346
Identified Species:
3.33
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S346
A
F
S
A
P
Q
N
S
E
S
Q
A
H
V
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
P346
A
F
S
A
P
Q
N
P
E
S
Q
A
H
V
S
Dog
Lupus familis
XP_531814
1283
145094
T329
E
D
F
L
N
S
C
T
P
G
M
R
K
W
W
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
E346
F
S
A
P
Q
N
S
E
S
Q
T
H
V
S
G
Rat
Rattus norvegicus
XP_002726765
1361
151628
E349
F
C
A
P
Q
N
S
E
S
Q
T
H
V
C
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
F450
A
K
S
K
L
T
L
F
A
A
P
E
N
F
E
Frog
Xenopus laevis
NP_001089247
1340
149481
F329
S
F
S
A
P
E
S
F
E
S
Q
A
N
T
G
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
F348
A
F
S
A
P
D
N
F
D
S
Q
S
S
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
L251
P
D
Y
D
K
S
T
L
H
V
P
E
K
F
L
Honey Bee
Apis mellifera
XP_392346
1120
127429
P181
N
N
V
I
D
S
W
P
H
L
K
Y
D
F
L
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
H247
L
W
V
P
P
D
F
H
Q
K
Q
T
P
G
H
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S328
G
T
P
S
G
Q
S
S
M
D
R
P
D
S
A
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
G336
K
V
L
F
F
K
M
G
K
F
Y
E
L
F
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
D329
G
L
E
D
N
V
L
D
G
D
A
L
A
R
F
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
I303
Y
D
P
R
T
L
Y
I
P
S
S
A
W
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
0
N.A.
0
0
N.A.
N.A.
13.3
53.3
53.3
N.A.
0
0
13.3
13.3
P-Site Similarity:
100
N.A.
93.3
6.6
N.A.
13.3
13.3
N.A.
N.A.
26.6
80
73.3
N.A.
0
6.6
26.6
40
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
27
0
14
27
0
0
0
0
7
7
7
27
7
7
7
% A
% Cys:
0
7
0
0
0
0
7
0
0
0
0
0
0
7
0
% C
% Asp:
0
20
0
14
7
14
0
7
7
14
0
0
14
0
0
% D
% Glu:
7
0
7
0
0
7
0
14
20
0
0
20
0
0
14
% E
% Phe:
14
27
7
7
7
0
7
20
0
7
0
0
0
27
7
% F
% Gly:
14
0
0
0
7
0
0
7
7
7
0
0
0
7
20
% G
% His:
0
0
0
0
0
0
0
7
14
0
0
14
14
0
7
% H
% Ile:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
7
7
0
7
7
7
0
0
7
7
7
0
14
0
7
% K
% Leu:
7
7
7
7
7
7
14
7
0
7
0
7
7
0
14
% L
% Met:
0
0
0
0
0
0
7
0
7
0
7
0
0
0
0
% M
% Asn:
7
7
0
0
14
14
20
0
0
0
0
0
14
7
7
% N
% Pro:
7
0
14
20
34
0
0
14
14
0
14
7
7
0
0
% P
% Gln:
0
0
0
0
14
20
0
0
7
14
34
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
7
7
0
7
0
% R
% Ser:
7
7
34
7
0
20
27
14
14
34
7
7
7
14
14
% S
% Thr:
0
7
0
0
7
7
7
7
0
0
14
7
0
7
0
% T
% Val:
0
7
14
0
0
7
0
0
0
7
0
0
14
14
0
% V
% Trp:
0
7
0
0
0
0
7
0
0
0
0
0
7
7
7
% W
% Tyr:
7
0
7
0
0
0
7
0
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _